The Prostatitis Foundation

Causes of Prostatitis
Prostate Cancer or Chronic Prostatitis

 

Does prostatitis lead to prostate cancer?

Prostate diseases tend to occur in order with prostatitis first, BPH second, and finally prostate cancer. Prostatitis starts in young men who can be in their teens, 20s, 30s, or 40s. BPH tends to occur in men over age 50 and prostate cancer is most often diagnosed in men in their 60s or 70s.

So, does prostatitis lead to prostate cancer?
One study showed an increased risk of prostate cancer in men with symptomatic prostatitis. See:

Nakarta S: Study of risk factors for prostatic cancer. Hinyokika Kiyo 1993;39(11):1017-1024.

Another study found that: "The relative odds of prostate cancer were elevated in men with history of any type of prostatitis." But the study was not good enough to be conclusive. See:

Roberts RO, Bergstralh EJ, Bass SE, Lieber MM, Jacobsen SJ.
Prostatitis as a risk factor for prostate cancer.
Epidemiology. 2004 Jan;15(1):93-9.

Another study found that: "Inflammation is frequently present in prostate biopsies, radical prostatectomy specimens and tissue resected for treatment of benign prostatic hyperplasia." See:

Platz EA, De Marzo AM.
Epidemiology of inflammation and prostate cancer.
J Urol. 2004 Feb;171(2 Pt 2):S36-40.

Another study decided to look at whether antiinflammatories to curb prostatitis, i.e. inflammation of the prostate, might help treat prostate cancer. See:

Pruthi RS, Derksen JE, Moore D.
A pilot study of use of the cyclooxygenase-2 inhibitor celecoxib in recurrent prostate cancer after definitive radiation therapy or radical prostatectomy.
BJU Int. 2004 Feb;93(3):275-8.

See also this talk:

"Sexually Transmitted Infections and Prostatitis in the Etiology of Prostate Cancer and Benign Prostatic Hyperplasia," an Epidemiology thesis defense seminar with Siobhan Sutcliff; W4013 SPH. EB
Johns Hopkins Gazette
http://www.jhu.edu/~gazette/2005/07mar05/weekcal.html

Prostatitis is often found when prostate cancer is removed. See:

Distribution of chronic prostatitis in radical prostatectomy specimens with up-regulation of bcl-2 in areas of inflammation. Gerstenbluth RE, Seftel AD, MacLennan GT, Rao RN, Corty EW, Ferguson K, Resnick MI. J Urol. 2002 May;167(5):2267-70.

 

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