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From: jdimitrakov@my-deja.com

Gemifloxacin

Note: The fluoroquinlone family of antibiotics has been problematic for prostatitis patients. They are frequently prescribed for prostatitis, but are not always effective. Many patients report serious side effects. See ciproeffects.html for more on this. Recently FDA issued a warning about a fluoroquinlone antibiotic, trovan, which had begun to be used for prostatitis. In vitro means "in the laboratory,", literally, "in glass." (Webmaster)

BIRMINGHAM, ENGLAND -- July 6, 1999 -The first in vitro data of SmithKline Beecham's new fluoroquinlone, gemifloxacin (SB-265805) was presented today at the 21st International Congress of Chemotherapy.
In one study, Dr. L. Kelly and colleagues, from the Hershey Medical Center, Hershey, PA. compared the activity of gemifloxacin with that of five other quinolones (ciprofloxacin, levofloxacin, sparfloxacin, grepafloxacin and trovafloxacin) as well as ampicillin, amoxycillin, cefixime, cefuroxime and azithromycin.
Although all the quinolones tested were very active against H. influenzae and M. catarrhalis, gemifloxacin had the lowest MIC values (MIC50 0.008 and 0.016 mcg/ml, respectively). Against nine quinolone-resistant H. influnzae strains the MIC50 of gemifloxacin was 0.25 mcg/ml, while that of all the other quinolones was 1mcg/ml.
"These data show that gemifloxacin is a very promising drug for the empiric treatment of community-acquired respiratory infections," Kelly said. Other posters show that gemifloxacin is also active against a wide variety of Gram-positive an Gram-negative organisms including S. aureus, E. coli, P. aeruginosa and Legionella.
Phase II dose-finding studies have been carried out and the drug is now going into Phase III trials with the first results expected later this year.

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