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Prostatitis and infertility

Abstracts on this page:
Webmaster's note |   Amtolmetin guacyl |   Gland Infection |   Antioxidant Capacity |   Culture Sensitivity |   Pathogenesis |   Sperm Examination |   Diagnosis and Localization |  Changes in the Genitalia |   Page Two of Infertility Abstracts |   Page three of Infertility Abstracts |   Page four of Infertility Abstracts |   Page five of Infertility Abstracts |   Page six of Infertility Abstracts |   Page seven of Infertility Abstracts |  
    Judi Martin wrote:
We got married just last year and wanting to have a baby but our fertility expert has found that my husband has low sperm count. He is found to have a prostatitis and suspected to have Epi and Orchitis. This is very sad moment for us and he was on the verge of suiciding..... ! Can you please please please help us with necessary information whether it is at all curable? Can his sperm become better? Can we have a baby of our own?
    Response:
The answer to your questions are unknowable because there are a lot of variables. But I know I have conceived children twice since I first had prostatitis. So it's not impossible.
At our search page, you can search everything on our site for words you are interested in such as "infertility," "sperm count," "epididymitis," "orchitis," etc. What you get in response to your searches there are the comments of other patients over the years. You may also find some abstracts from scientific papers.
There are many possible causes to prostatitis, including neurological-muscular tension disorders, bacterial infection or infection by other pathogens such as yeasts or viruses, and the possibility that prostatitis is a disordered immune response. The very best doctors have a difficult time proving to themselves which it is, and even when they are sure, they do not all have really high rates of cure...Does this mean you or your husband should give up? I don't think so.
    The reasons not to give up include:
  1. Your husband has something that millions of men have and he can take some solace in communicating with other men with prostatitis. We're working together through The Prostatitis Foundation to get some of the scientific questions answered.
  2. By talking to each other, men with prostatitis have flushed out of the woodworks some things which are helpful, but which were not widely known, or widely appreciated, before we got together on the Internet. Among these are Quercetin, which helps men who do not seem to have active bacterial infections, and "drainage," which is very firm massage of of the prostate gland to squeeze out the contents. ALL interventions in prostatitis have some risks, and NONE work for everybody. But these and other tools that your doctor may not know about or recommend can help. Note that many spouses do drainage themselves to help their husbands reduce prostatitis symptoms.
  3. Many men with prostatitis have managed to conceive children.
    One correspondent wrote:
I've had abacterial CP for almost two years. My wife is about two months pregnant right now, and we succeeded in becoming pregnant in only her second cycle (she's 39, btw). Our previous pregnancy occurred the first time we didn't use contraception. In short, prostatitis slowed us down from the first ovulation to the second ovulation. Woo woo. I wouldn't sweat the fertility thing.

Abstracts:

(back to top) NLM CIT. ID: 20060118
Male urogenital amicrobial phlogosis: effects of the treatment with amtolmetin guacyl on some sperm parameters
Vicari E; Cataldo T; Arancio A; D'Agata R, Cattedra Andrologia, Universita di Catania, Italia.
Arch Ital Urol Androl 1999 Sep;71(4):211-21
To examine if some inflammation-related sperm abnormalities were influenced by leucocytospermia (swbc) alone, WBC-specific Radical Oxygen species (WBC-ROS) over-production, and/or by different infected sexual gland sites and if these abnormalities were possibly reversible following treatment with an antiphlogistic drug, a total of 43 infertile male patients with amicrobial male accessory gland infections (MAGI) associated with prostatitis (P, n = 16), prostato-vesiculitis (PV, n = 14) or prostato-vesiculo-epididymitis (PVE, n = 13) as confirmed by ultrasound, were studied. The patients were then further subdivided into two subsets: one of the subsets (P, N = 10; PV, n = 8; PVE, n = 7) was administered amtolmetina guacyl (Eufans) 600 mg once daily for 14 consecutive days per month, for a 2-months period. The second subset (six patients for each category) received no treatment (matched-control). Mean outcome measures included a follow-up of sperm analysis with assessment of sperm forward motility (M), sperm viability (V). In addition, swbc as well as basal and maximal fmlp-mediated WBC- ROS production were also carried out by conventional immunocytochemistry staining and chemiluminescence analysis respectively. In the pre-treatment, in all patients (treated and not treated subsets) median values of the sperm M and V were significantly different among categories (P > PV > PVE), and necrozoospermia (sperm viability < 25%) were present in the 70% out of group P patients and in all (100%) patients from groups PV and PVE. Median swbc concentrations, elevated (values > 1 mil/ml) in all groups, in the PV and PVE groups were significantly higher compared to those found in the group P. Furthermore, PVE group generated baseline and fmlp-stimulated ROS productions from low density 45% Percoll fraction (Pc45), significantly higher than those found in P or PV groups. Sperm outcome measures were significantly different compared with the matched-controls (exhibiting 0% case-responders), in a time- and infected gland site-dependent manner. Thus, either in terms of median values and percentages of responders (defined as parameters ensued within the conventional normal range) sperm M and V percentages, as well as swbc improved after the first (T1) antiphlogistic course in the group P only, but after the second (T2) antiphlogistic course in the other groups (PV or PVE). Moreover, treated patients of each group had amounts of generated basal and fmlp-stimulated ROS signals significantly reduced, with values ensued within a fertile control range at T2, in 80, 62.5 and 42.8% out of the P, PV and PVE groups respectively. We concluded that long-term amtolmetina-guacyl administration demonstrated efficacy and safety in the treatment of amicrobial MAGI, exhibiting a positive impact on all sperm parameters studied and no side-effects.
(back to top) NLM CIT. ID: 20047606
Relevance of male accessory gland infection for subsequent fertility, with special focus on prostatitis
Weidner W; Krause W; Ludwig M, Department of Urology, University of Giessen, Germany.
Infections of the male genitourinary tract may contribute to infertility to a various extent depending on the site of inflammation. Especially in prostatitis, the exact classification of the infection contributes to its impact on changes in the ejaculate. Similarly, in urethritis, epididymitis and orchitis, only a clear clinical diagnosis allows a rational approach to altered sperm parameters. Several inflammatory and reactive alterations of sperm quality seem to be proven; nevertheless, the impact of these findings on male fertility remains in many cases unclear. Even therapeutic trials do not provide more insights into the association of male genital infections and impaired fertility, although the efficacy of antibiotic trials seems to be proven. For the future, it may be decisive to evaluate inflammatory changes in the ejaculate not only on the basis of standard but also on functional parameters, thus providing new definitions of the interactions between male urogenital tract infection and disturbances of male fertility.
(back to top)  NLM CIT. ID: 20018218
The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility.
Sharma RK; Pasqualotto FF; Nelson DR; Thomas AJ Jr Agarwal A, Center for Advanced Research in Human Reproduction and Infertility, Departments of Urology, Gynecology-Obstetrics, Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
The imbalance between reactive oxygen species (ROS) production and total antioxidant capacity (TAC) in seminal fluid indicates oxidative stress and is correlated with male infertility. A composite ROS-TAC score may be more strongly correlated with infertility than ROS or TAC alone. We measured ROS, TAC, and ROS-TAC scores in semen from 127 patients and 24 healthy controls. Of the patients, 56 had varicocele, eight had varicocele with prostatitis, 35 had vasectomy reversals, and 28 had idiopathic infertility. ROS levels were higher among infertile men, especially those with varicocele with prostatitis (mean +/- SE, 3.25 +/- 0.89) and vasectomy reversals (2.65 +/- 1.01). all infertile groups had significantly lower ROS-TAC scores than control. ROS-TAC score identified 80% of patients and was significantly better than ROS at identifying varicocele and idiopathic infertility. The 13 patients whose partners later achieved pregnancies had a mean ROS-TAC score of 47.7 +/- 13.2, similar to controls but significantly higher than the 39 patients who remained infertile (35.8 +/- 15.0; P < 0.01). ROS-TAC score is a novel measure of oxidative stress and is superior to ROS or TAC alone in discriminating between fertile and infertile men. Infertile men with male factor or idiopathic diagnoses had significantly lower ROS-TAC scores than controls, and men with male factor diagnoses that eventually were able to initiate a successful pregnancy had Significantly higher ROS-TAC scores than those who failed.
(back to top)  NLM CIT. ID: 99428087
Bacteriospermia and male infertility: a method for increasing the sensitivity of semen culture
Villanueva-Diaz CA; Flores-Reyes GA Beltran-Zuniga M; Echavarria-Sanchez M; Ortiz-Ibarra FJ Arredondo-Garcia JL, Departamento de Androloga, Mexico, D.F., Mexico.
Objective:
To test a method for increasing the sensitivity of semen Culture. Design-Prospective and transverse. Setting-Andrology clinic At a tertiary care health institution in Mexico City.
Patients
65 Infertile patients with abnormal semen, bacteriospermia detected on Gram stain and at least two previous negative semen cultures (<<3 Months) were included to test routine semen culture and a method Including centrifugation of semen at 10,00 rpm for 20 minutes. Localization cultures were also carried out in all patients.
Main Outcome Measure:
Bacterial isolation in semen samples.
Results:
Routine semen culture was positive in 22% of patients, while Centrifuged aliquots of the same semen sample were positive in 52% of Patients (chi2 = 6.60, P <.01). Enterococcus was isolated in 43% of Patients, E. Coli in 24%, coagulase-negative Staphylococcus in 19%, And U. Urealyticum in 14%. Ninety percent of isolates corresponded to Specimens from the urethra and the prostato-vesicular region.
Conclusion
Sensitivity of semen culture increased with Centrifugation of semen samples. Localization pattern and type of Isolates suggest that these patients had chronic prostatitis and that Episodic elimination of bacteria might also explain false negative Semen cultures in patients with chronic asymptomatic infection of the Accessory sex glands.
(back to top)  NLM CIT. ID: 98360684
An analysis of variance of the integration of the vascular and germinative testicular systems in the pathogenesis of infertility
In 162 infertile patients and 404 rats an impact was evaluated of Varicocele, cryptorchidism, epididymitis, prostatitis, obstruction of The deferent ducts and effects of the electromagnetic field on the Amounts and volume of spermatogonia nuclei. Sertoli cells, Leydig's Cells, the number and outer diameter of arterioles, capillaries and Venules. The impact of the above illnesses is at its greatest in Respect of the spermatogenic epithelium, with lesser effects being Exerted on the parameters of the hemomicrocirculatory bed, the most Measurable changes in which occur with microvessels of the venular Link. In the pathogenesis of infertility there takes place an Interaction between the germinal system and hemomicrocirculatory bed Of the testicle.
(back to top)  NLM CIT. ID: 98344276
The effect of prostaglandin E1 on in vitro transcription of sperm Chromatin, isolated from patients with azoospermia, teratospermia and Chronic prostatitis.
Pironcheva G; Miteva K; Russev GC; Vaisberg C Zlatarev S, Institute of Molecular Biology, Bulg. Acad. Sci., Sofia, Bulgaria.
We have investigated the influence of Prostaglandin E1 on the in vitro Transcription of chromatin, isolated from spermatozoa of patients Suffering from different pathologies, leading to infertility, namely, Azoospermia, teratospermia and chronic prostatitis. Our studies Indicate that prostaglandin E1 has a stimulatory effect both on in Vitro transcription, on the number of RNA polymerase molecules and The polyribonucleotide elongation rates as compared to sperm Chromatin from healthy patients. The results on the incorporation of Alpha-32P-ATP in to RNA in the presence and absence of Prostaglandin E1 correlate well with the data on the number of actively Transcribing RNA polymerase molecules and the rate of RNA elongation, Which might be due to low levels of prostaglandin E1 in human semen. (back to top)
 NLM CIT. ID: 98274288
Prostatic fluid and sperm examination: 106 cases. Preliminary study on Infertility
Huaijin C; Junyan Z; Naiguan C, Department of Urology, International Peace Hospital, Shanghai, China.
Objective:
This research is designed to explore the relationship Between the results of routine prostatic fluid and sperm examination Obtained from 106 married male young people. METHODS: The subject of The present research included 106 married young men who underwent Pre- martial checkups. Leukocyte count, ph value, and lecithin body In prostatic fluid were measured and compared with the data of sperm Examination.
Results:
The results showed that when leukocyte count in Prostatic fluid was over 10/HPF, the survival rate of sperms Decreased significantly, liquefying time prolonged significantly (p < 0.001), sperms decreased in number from 54.42 million/mm3 to 38.93 Million/mm3 with rise in ph value.
Conclusions:
Our research reveals A positive correlation between increased leukocytes in prostatic Fluid and infertility.
NLM PUBMED CIT. ID: 9611354
SOURCE: Acta Urol Belg 1998 Mar;66(1):19-21
(back to top) NLM CIT. ID: 98131934
Diagnosis and localization of a complicated urinary tract infection in neurogenic bladder disease by tubular proteinuria and serum prostate specific antigen.
Everaert K; Oostra C; Delanghe J; Vande Walle J Van Laere M; Oosterlinck W, Department of Urology, University of Ghent, Belgium.
Introduction:Urinary tract infection is the most frequent Complication occurring in patients with spinal cord injuries and can Cause renal failure and male infertility. We used the urinary Alpha-1-microglobulin (alpha 1Mg) as a marker for pyelonephritis and The serum prostate specific antigen (PSA) as a marker for prostatitis With reference to the currently available methods. The aim of our Study is (1) to differentiate between upper (pyelonephritis) and Lower urinary tract infection (cystitis, prostatitis) in neurogenic Bladder disease, (2) to determine if high (< or = 38.5 degrees C) Fever in a neurogenic bladder disease patient was due to urological (prostatitis, pyelonephritis) causes or not.
Patients and Methods: We Evaluated 147 patients of whom 27 had acute pyelonephritis, 16 had Prostatitis with fever, 13 had chronic pyelonephritis, 68 had Cystitis; 23 were control patients of whom nine had fever (< or = 38.5 degrees C) and 14 did not. The diagnoses and localizations were Made on the basis of clinical evidence, with a CT scan, urography, Bladder wash-out tests, and five glass-specimen tests. The urinary Alpha 1Mg was determined using latex enhanced immunonephelometry and The serum PSA was measured using RIA.
Results:
For the urinary alpha 1Mg, the sensitivity is 96% and the specificity 93% for the diagnosis Of acute pyelonephritis. The serum PSA has a sensitivity of 69% and Specificity of 96% in the diagnosis of prostatitis. The urinary alpha 1Mg has a sensitivity of 96% and a specificity of 56% and the serum PSA has a sensitivity of 68% and a specificity of 100% in the Differential diagnosis of prostatitis and pyelonephritis. The best Discriminative parameter between pyelonephritis and prostatitis was The urinary alpha 1Mg/serum PSA ratio with a sensitivity of 92% and Specificity of 88%.
Conclusion
Upper-tract infection with fever can Be diagnosed in neurogenic bladder disease by determining the urinary Alpha 1Mg. In male patients, the serum PSA should be determined to Distinguish upper-tract infection from prostatitis. High fever does Not significantly influence our parameters so that we can Differentiate whether or not high fever is due to urological causes.
NLM PUBMED CIT. ID: 9471136
SOURCE: Spinal Cord 1998 Jan;36(1):33-8
(back to top) NLM CIT. ID: 97446716
The interaction of changes in the genitalia in the pathogenesis of Sterility in men
Malyshkin IN
Alterations in testicular structures on the side of the pathologic Process, contralateral testicle, epididymis, deferent duct, prostate, Spermogramme, were found out to be related to the level of Gonadotrophic and sex hormones in pathogenesis of infertility Developing in varicocele, cryptorchidism, epididymitis, prostatitis, Obstruction of the deferent duct, and action of low frequency Electromagnetic field. The findings obtained will, we believe, help In diagnosing and prescribing the pathogenetically substantiated Treatment.
NLM PUBMED CIT. ID: 9377363
SOURCE: Lik Sprava 1997 May-Jun;(3):83-7
Webmaster's note:
Thanks to Dr. Sandra Mazzoli, we have more than 100 abstracts on infertility and prostatitis on our site. Putting them all on one page, however, makes the page unweildy and slow to load on even the fastest connections. Therefor the abstracts on prostatitis and infertility are spread over 8 total pages, named "infertility.html," "intertility2.html," "infertility3.html" and so on. Depending on when you access this information, some of the dependent pages ("infertility2.html"..."infertility7.html") may not be completely formatted. We're working on it. Go back to the top to find links to the rest of the abstracts.
August 17, 2000

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