|Abstracts on this page:
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Amtolmetin guacyl |
Gland Infection |
Antioxidant Capacity |
Culture Sensitivity |
Sperm Examination |
Diagnosis and Localization | Changes in the Genitalia |
Page Two of Infertility Abstracts |
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| Judi Martin wrote:
|We got married just last year and wanting to have a baby but our fertility expert has found that my husband has low sperm count. He is found to have a prostatitis and suspected to have Epi and Orchitis. This is very sad moment for us and he was on the verge of suiciding..... ! Can you please please please help us with necessary information whether it is at all curable? Can his sperm become better? Can we have a baby of our own?
The answer to your questions are unknowable because there are a lot of variables. But I know I have conceived children twice since I first had prostatitis. So it's not impossible.
At our search page, you can search everything on our site for words you are interested in such as "infertility," "sperm count," "epididymitis," "orchitis," etc. What you get in response to your searches there are the comments of other patients over the years. You may also find some abstracts from scientific papers.
|There are many possible causes to prostatitis, including neurological-muscular tension disorders, bacterial infection or infection by other pathogens such as yeasts or viruses, and the possibility that prostatitis is a disordered immune response. The very best doctors have a difficult time proving to themselves which it is, and even when they are sure, they do not all have really high rates of cure...Does this mean you or your husband should give up? I don't think so.
The reasons not to give up include:
- Your husband has something that millions of men have and he can take some solace in communicating with other men with prostatitis. We're working together through The Prostatitis Foundation to get some of the scientific questions answered.
- By talking to each other, men with prostatitis have flushed out of the woodworks some things which are helpful, but which were not widely known, or widely appreciated, before we got together on the Internet. Among these are Quercetin, which helps men who do not seem to have active bacterial infections, and "drainage," which is very firm massage of of the prostate gland to squeeze out the contents. ALL interventions in prostatitis have some risks, and NONE work for everybody. But these and other tools that your doctor may not know about or recommend can help. Note that many spouses do drainage themselves to help their husbands reduce prostatitis symptoms.
- Many men with prostatitis have managed to conceive children.
| One correspondent wrote:
|I've had abacterial CP for almost two years. My wife
is about two months pregnant right now, and we succeeded
in becoming pregnant in only her second cycle (she's 39,
btw). Our previous pregnancy occurred the first time
we didn't use contraception. In short, prostatitis slowed
us down from the first ovulation to the second ovulation.
Woo woo. I wouldn't sweat the fertility thing.
|(back to top) NLM CIT. ID: 20060118
Male urogenital amicrobial phlogosis: effects of the treatment with amtolmetin guacyl on some sperm parameters
Vicari E; Cataldo T; Arancio A; D'Agata R,
Cattedra Andrologia, Universita di Catania, Italia.
Arch Ital Urol Androl 1999 Sep;71(4):211-21
To examine if some inflammation-related sperm abnormalities were
influenced by leucocytospermia (swbc) alone, WBC-specific Radical
Oxygen species (WBC-ROS) over-production, and/or by different
infected sexual gland sites and if these abnormalities were possibly
reversible following treatment with an antiphlogistic drug, a total
of 43 infertile male patients with amicrobial male accessory gland
infections (MAGI) associated with prostatitis (P, n = 16),
prostato-vesiculitis (PV, n = 14) or prostato-vesiculo-epididymitis
(PVE, n = 13) as confirmed by ultrasound, were studied. The patients
were then further subdivided into two subsets: one of the subsets (P,
N = 10; PV, n = 8; PVE, n = 7) was administered amtolmetina guacyl
(Eufans) 600 mg once daily for 14 consecutive days per month, for a
2-months period. The second subset (six patients for each category)
received no treatment (matched-control). Mean outcome measures
included a follow-up of sperm analysis with assessment of sperm
forward motility (M), sperm viability (V). In addition, swbc as well
as basal and maximal fmlp-mediated WBC- ROS production were also
carried out by conventional immunocytochemistry staining and
chemiluminescence analysis respectively. In the pre-treatment, in all
patients (treated and not treated subsets) median values of the sperm
M and V were significantly different among categories (P > PV > PVE),
and necrozoospermia (sperm viability < 25%) were present in the 70%
out of group P patients and in all (100%) patients from groups PV and
PVE. Median swbc concentrations, elevated (values > 1 mil/ml) in all
groups, in the PV and PVE groups were significantly higher compared
to those found in the group P. Furthermore, PVE group generated
baseline and fmlp-stimulated ROS productions from low density 45%
Percoll fraction (Pc45), significantly higher than those found in P
or PV groups. Sperm outcome measures were significantly different
compared with the matched-controls (exhibiting 0% case-responders),
in a time- and infected gland site-dependent manner. Thus, either in
terms of median values and percentages of responders (defined as
parameters ensued within the conventional normal range) sperm M and V
percentages, as well as swbc improved after the first (T1)
antiphlogistic course in the group P only, but after the second (T2)
antiphlogistic course in the other groups (PV or PVE). Moreover,
treated patients of each group had amounts of generated basal and
fmlp-stimulated ROS signals significantly reduced, with values ensued
within a fertile control range at T2, in 80, 62.5 and 42.8% out of
the P, PV and PVE groups respectively. We concluded that long-term
amtolmetina-guacyl administration demonstrated efficacy and safety in
the treatment of amicrobial MAGI, exhibiting a positive impact on all
sperm parameters studied and no side-effects.
(back to top)
NLM CIT. ID: 20047606
Relevance of male accessory gland infection for subsequent fertility, with special focus on prostatitis
Weidner W; Krause W; Ludwig M,
Department of Urology, University of Giessen, Germany.
Infections of the male genitourinary tract may contribute to
infertility to a various extent depending on the site of
inflammation. Especially in prostatitis, the exact classification of
the infection contributes to its impact on changes in the ejaculate.
Similarly, in urethritis, epididymitis and orchitis, only a clear
clinical diagnosis allows a rational approach to altered sperm
parameters. Several inflammatory and reactive alterations of sperm
quality seem to be proven; nevertheless, the impact of these findings
on male fertility remains in many cases unclear. Even therapeutic
trials do not provide more insights into the association of male
genital infections and impaired fertility, although the efficacy of
antibiotic trials seems to be proven. For the future, it may be
decisive to evaluate inflammatory changes in the ejaculate not only
on the basis of standard but also on functional parameters, thus
providing new definitions of the interactions between male urogenital
tract infection and disturbances of male fertility.
(back to top)
NLM CIT. ID: 20018218
The reactive oxygen species-total antioxidant capacity score is a new
measure of oxidative stress to predict male infertility.
Sharma RK; Pasqualotto FF; Nelson DR; Thomas AJ Jr
Center for Advanced Research in Human Reproduction and Infertility,
Departments of Urology, Gynecology-Obstetrics, Biostatistics and
Epidemiology, The Cleveland Clinic Foundation, Cleveland, OH 44195,
The imbalance between reactive oxygen species (ROS) production and
total antioxidant capacity (TAC) in seminal fluid indicates oxidative
stress and is correlated with male infertility. A composite ROS-TAC
score may be more strongly correlated with infertility than ROS or
TAC alone. We measured ROS, TAC, and ROS-TAC scores in semen from 127
patients and 24 healthy controls. Of the patients, 56 had varicocele,
eight had varicocele with prostatitis, 35 had vasectomy reversals,
and 28 had idiopathic infertility. ROS levels were higher among
infertile men, especially those with varicocele with prostatitis
(mean +/- SE, 3.25 +/- 0.89) and vasectomy reversals (2.65 +/- 1.01).
all infertile groups had significantly lower ROS-TAC scores than
control. ROS-TAC score identified 80% of patients and was
significantly better than ROS at identifying varicocele and
idiopathic infertility. The 13 patients whose partners later achieved
pregnancies had a mean ROS-TAC score of 47.7 +/- 13.2, similar to
controls but significantly higher than the 39 patients who remained
infertile (35.8 +/- 15.0; P < 0.01). ROS-TAC score is a novel measure
of oxidative stress and is superior to ROS or TAC alone in
discriminating between fertile and infertile men. Infertile men with
male factor or idiopathic diagnoses had significantly lower ROS-TAC
scores than controls, and men with male factor diagnoses that
eventually were able to initiate a successful pregnancy had
Significantly higher ROS-TAC scores than those who failed.
(back to top)
NLM CIT. ID: 99428087
Bacteriospermia and male infertility: a method for increasing the
sensitivity of semen culture
Villanueva-Diaz CA; Flores-Reyes GA
Beltran-Zuniga M; Echavarria-Sanchez M; Ortiz-Ibarra FJ
Departamento de Androloga, Mexico, D.F., Mexico.
To test a method for increasing the sensitivity of semen
Culture. Design-Prospective and transverse. Setting-Andrology clinic
At a tertiary care health institution in Mexico City.
Infertile patients with abnormal semen, bacteriospermia detected on
Gram stain and at least two previous negative semen cultures (<<3
Months) were included to test routine semen culture and a method
Including centrifugation of semen at 10,00 rpm for 20 minutes.
Localization cultures were also carried out in all patients.
Main Outcome Measure:
Bacterial isolation in semen samples.
Routine semen culture was positive in 22% of patients, while
Centrifuged aliquots of the same semen sample were positive in 52% of
Patients (chi2 = 6.60, P <.01). Enterococcus was isolated in 43% of
Patients, E. Coli in 24%, coagulase-negative Staphylococcus in 19%,
And U. Urealyticum in 14%. Ninety percent of isolates corresponded to
Specimens from the urethra and the prostato-vesicular region.
Sensitivity of semen culture increased with
Centrifugation of semen samples. Localization pattern and type of
Isolates suggest that these patients had chronic prostatitis and that
Episodic elimination of bacteria might also explain false negative
Semen cultures in patients with chronic asymptomatic infection of the
Accessory sex glands.
(back to top)
NLM CIT. ID: 98360684
An analysis of variance of the integration of the vascular and
germinative testicular systems in the pathogenesis of infertility
In 162 infertile patients and 404 rats an impact was evaluated of
Varicocele, cryptorchidism, epididymitis, prostatitis, obstruction of
The deferent ducts and effects of the electromagnetic field on the
Amounts and volume of spermatogonia nuclei. Sertoli cells, Leydig's
Cells, the number and outer diameter of arterioles, capillaries and
Venules. The impact of the above illnesses is at its greatest in
Respect of the spermatogenic epithelium, with lesser effects being
Exerted on the parameters of the hemomicrocirculatory bed, the most
Measurable changes in which occur with microvessels of the venular
Link. In the pathogenesis of infertility there takes place an
Interaction between the germinal system and hemomicrocirculatory bed
Of the testicle.
(back to top)
NLM CIT. ID: 98344276
The effect of prostaglandin E1 on in vitro transcription of sperm
Chromatin, isolated from patients with azoospermia, teratospermia and
Pironcheva G; Miteva K; Russev GC; Vaisberg C
Institute of Molecular Biology, Bulg. Acad. Sci., Sofia, Bulgaria.
We have investigated the influence of Prostaglandin E1 on the in vitro
Transcription of chromatin, isolated from spermatozoa of patients
Suffering from different pathologies, leading to infertility, namely,
Azoospermia, teratospermia and chronic prostatitis. Our studies
Indicate that prostaglandin E1 has a stimulatory effect both on in
Vitro transcription, on the number of RNA polymerase molecules and
The polyribonucleotide elongation rates as compared to sperm
Chromatin from healthy patients. The results on the incorporation of
Alpha-32P-ATP in to RNA in the presence and absence of Prostaglandin
E1 correlate well with the data on the number of actively
Transcribing RNA polymerase molecules and the rate of RNA elongation,
Which might be due to low levels of prostaglandin E1 in human semen.
(back to top)
NLM CIT. ID: 98274288
Prostatic fluid and sperm examination: 106 cases. Preliminary study on
Huaijin C; Junyan Z; Naiguan C,
Department of Urology, International Peace Hospital, Shanghai, China.
This research is designed to explore the relationship
Between the results of routine prostatic fluid and sperm examination
Obtained from 106 married male young people. METHODS: The subject of
The present research included 106 married young men who underwent
Pre- martial checkups. Leukocyte count, ph value, and lecithin body
In prostatic fluid were measured and compared with the data of sperm
The results showed that when leukocyte count in
Prostatic fluid was over 10/HPF, the survival rate of sperms
Decreased significantly, liquefying time prolonged significantly (p <
0.001), sperms decreased in number from 54.42 million/mm3 to 38.93
Million/mm3 with rise in ph value.
Our research reveals
A positive correlation between increased leukocytes in prostatic
Fluid and infertility.
NLM PUBMED CIT. ID:
SOURCE: Acta Urol Belg 1998 Mar;66(1):19-21
(back to top)
NLM CIT. ID: 98131934
Diagnosis and localization of a complicated urinary tract infection in
neurogenic bladder disease by tubular proteinuria and serum prostate
Everaert K; Oostra C; Delanghe J; Vande Walle J
Van Laere M; Oosterlinck W,
Department of Urology, University of Ghent, Belgium.
Introduction:Urinary tract infection is the most frequent
Complication occurring in patients with spinal cord injuries and can
Cause renal failure and male infertility. We used the urinary
Alpha-1-microglobulin (alpha 1Mg) as a marker for pyelonephritis and
The serum prostate specific antigen (PSA) as a marker for prostatitis
With reference to the currently available methods. The aim of our
Study is (1) to differentiate between upper (pyelonephritis) and
Lower urinary tract infection (cystitis, prostatitis) in neurogenic
Bladder disease, (2) to determine if high (< or = 38.5 degrees C)
Fever in a neurogenic bladder disease patient was due to urological
(prostatitis, pyelonephritis) causes or not.
Patients and Methods: We
Evaluated 147 patients of whom 27 had acute pyelonephritis, 16 had
Prostatitis with fever, 13 had chronic pyelonephritis, 68 had
Cystitis; 23 were control patients of whom nine had fever (< or =
38.5 degrees C) and 14 did not. The diagnoses and localizations were
Made on the basis of clinical evidence, with a CT scan, urography,
Bladder wash-out tests, and five glass-specimen tests. The urinary
Alpha 1Mg was determined using latex enhanced immunonephelometry and
The serum PSA was measured using RIA.
For the urinary alpha
1Mg, the sensitivity is 96% and the specificity 93% for the diagnosis
Of acute pyelonephritis. The serum PSA has a sensitivity of 69% and
Specificity of 96% in the diagnosis of prostatitis. The urinary alpha
1Mg has a sensitivity of 96% and a specificity of 56% and the serum
PSA has a sensitivity of 68% and a specificity of 100% in the
Differential diagnosis of prostatitis and pyelonephritis. The best
Discriminative parameter between pyelonephritis and prostatitis was
The urinary alpha 1Mg/serum PSA ratio with a sensitivity of 92% and
Specificity of 88%.
Upper-tract infection with fever can
Be diagnosed in neurogenic bladder disease by determining the urinary
Alpha 1Mg. In male patients, the serum PSA should be determined to
Distinguish upper-tract infection from prostatitis. High fever does
Not significantly influence our parameters so that we can
Differentiate whether or not high fever is due to urological causes.
NLM PUBMED CIT. ID:
SOURCE: Spinal Cord 1998 Jan;36(1):33-8
(back to top)
NLM CIT. ID: 97446716
The interaction of changes in the genitalia in the pathogenesis of
Sterility in men
Alterations in testicular structures on the side of the pathologic
Process, contralateral testicle, epididymis, deferent duct, prostate,
Spermogramme, were found out to be related to the level of
Gonadotrophic and sex hormones in pathogenesis of infertility
Developing in varicocele, cryptorchidism, epididymitis, prostatitis,
Obstruction of the deferent duct, and action of low frequency
Electromagnetic field. The findings obtained will, we believe, help
In diagnosing and prescribing the pathogenetically substantiated
NLM PUBMED CIT. ID:
SOURCE: Lik Sprava 1997 May-Jun;(3):83-7
Thanks to Dr. Sandra Mazzoli, we have more than 100 abstracts on infertility and prostatitis on our site. Putting them all on one page, however, makes the page unweildy and slow to load on even the fastest connections. Therefor the abstracts on prostatitis and infertility are spread over 8 total pages, named "infertility.html," "intertility2.html," "infertility3.html" and so on. Depending on when you access this information, some of the dependent pages ("infertility2.html"..."infertility7.html") may not be completely formatted. We're working on it. Go back to the top to find links to the rest of the abstracts.
August 17, 2000
The mission of the Prostatitis Foundation is to educate the public about the prevalence of prostatitis
and encourage and support research to find the cause and a cure for prostatitis.
We're sorry you are having to learn about prostatitis, but we're glad you came here, because we think we can help. Please be advised that the Prostatitis Foundation does
not warrant, support, sponsor, endorse, recommend or accept responsibility for any health care provider or any treatment or protocol performed by any heath care provider.