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Prostatitis Foundation

Third International Chronic Prostatitis Network

Strategies for identifying prostatitis–Predisposing genetic loci

D.E. Riley, J.N. Krieger
Molecular Laboratory, Urology, University of Washington School of Medicine, Seattle, WA
Genetic background is important in urological disorders such as prostate cancer, hypospadias, and androgen insensitivity. In women, the risk of recurrent urinary tract infection clearly reflects genetic background, e.g., blood group antigen and secretor status. Previous investigators have used weakly polymorphic sites to find associations of genetic loci with prostate diseases such as prostate cancer.
Newly available human genome sequencing data was searched for highly polymorphic short tandem repeats (STRs) near loci previously implicated in prostate diseases. The international human gene mapping consortium, Genemap, was used to locate, with high resolution, prostate disease-predisposing sites. Sequence data from the Human Genome Sequencing Project were searched for STRs near predisposing loci. PCR primers were then designed to test the STRs for polymorphism in a panel of DNA samples from clinical populations.
We identified two promising STRs. One STR, located 3 inches to the human phosphoglycerate kinase (PGK1) gene, is hemizygous, and exhibited 9 distinct alleles. This represents the most pleomorphic site identified to date in this region. The second STR, in the region of the glutamate receptor gene (GLU1), is located near the terminus of the long arm of the X chromosome, a region implicated in familial prostate cancer.
Newly available genetic techniques should allow us to determine the relative importance of genetic and environmental factors in chronic prostatitis/chronic pelvic pain syndrome.
© 2002 The Prostatitis Foundation
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