The Prostatitis Foundation

Prostatitis and infertility


(back to top) NLM CIT. ID:87193339
Zinc in human semen
Canale D; Bartelloni M; Negroni A; Meschini P Izzo PL; Bianchi B; Menchini-Fabris GF
Seminal zinc was measured in normospermic and infertile patients by a New colorimetric method. Analysis of semen from 5 patients with Bilateral agenesis of the vas deferens showed high levels of zinc (mean value 1411.2 micrograms/ml). Lower levels were found in 6 Patients with monolateral congenital or acquired obstruction (695.2 Micrograms/ml). The seminal zinc level in 6 patients who had had a Vasectomy or who had an epididymal blockage (125.7 micrograms/ml) was Approximately the same as in 41 controls (134.6 +/- 42 +/- SD). Zinc Levels were reduced in hypogonadal patients. These data suggest that Zinc is secreted mainly by the prostate, while vesicular, epididymal And testicular secretions are devoid of zinc. Evaluation of this Metal therefore permits the diagnosis of patency of the seminal Pathways, but does not permit identification of prostatitis. No Correlation was found between sperm count or motility and the seminal Zinc level, nor between the latter and varicocele.
SOURCE: Int J Androl 1986 Dec;9(6):477-80 77
(back to top) NLM CIT. ID: 87112664
Immunosuppression and sperm antibody formation in men with Prostatitis.
Witkin SS; Zelikovsky G
16 men with chronic prostatitis were evaluated immunologically in Order to examine possible relationships between prostate infection, Defective cellular immune responses and the occurrence of sperm Antibodies. Peripheral blood mononuclear cells (PBMN) from 14 of 16 (88%) patients exhibited reduced or absent responses in vitro when Incubated with an extract of Candida albicans. PBMN proliferation in Response to the mitogen Concanavalin A (Con A) was reduced in 5 of 16 (31%) men. In addition, sera from 6 patients inhibited the Candida-induced proliferative response of control PBMC; 2 of these Sera also reduced the Con A-directed response. Sperm antibodies, Evaluated by an enzyme- linked immunosorbent assay (ELISA) using Fresh motile spermatozoa, were found in 9 of 16 (56%) patients. PBMC Responses were reduced in all, and suppressive sera present in 5, of The men with sperm antibodies. Igg antibodies predominated. 4 of the Sera positive by ELISA also agglutinated spermatozoa. Levels of igg Sperm antibodies were correlated with the degree of immunosuppression By patient sera (p less than 0.02). These data suggest that decreased Cellular immunity and enhanced humoral reactivity to sperm are common In men with chronic prostatitis. Both may contribute to an increased Rate of prostatic infection in these men.
SOURCE: J Clin Lab Immunol 1986 Sep;21(1):7-10 79
(back to top) NLM CIT. ID: 86290812
Significance and problems of Chlamydia detection in urologic Patients]
VERNACULAR TITLE: Bedeutung und Problematik des Chlamydiennachweises bei urologischen Patienten.
Krech T; Gerhard-Fsadni D; Miller SM; Hofmann N
Chlamydiae represent the aetiological agent in non-gonococcal Urethritis in about 50% of the cases, but it is also increasingly Recognized that Chlamydia trachomatis can cause prostatitis or Epididymitis. The introduction of methods for the direct detection of Chlamydia in clinical materials allows early diagnosis and therefore Effective antibiotic therapy. The new tests however give both false Positive and false negative results.
SOURCE: Urologe [A] 1986 May;25(3):153-6 80
(back to top) NLM CIT. ID: 87082350
The effect of doxycycline in infertile couples with male accessory Gland infection: a double blind prospective study.
Comhaire FH; Rowe PJ; Farley TM
Male accessory gland infection (MAGI, epididymo-prostato-vesiculitis) With abnormal semen quality was rarely the only abnormality in Infertile couples since it occurred in no more than 1.6% of 2871 Couples evaluated in 7 centres during a 3-year period. Both partners Of 33 infertile couples with no other demonstrable abnormality than Abnormal semen and MAGI consented to participate in a double blind Trial and were treated with either doxycycline, 100 mg/day for 1 Month (20 couples) or placebo (13 couples). Follow-up during a total Of 175 couple-months included semen analysis and the recording of Pregnancy. Pregnancy occurred in 2 of the doxycycline-treated couples (10%) and in 1 of the placebo treated couples (8%), corresponding With conception rates per month of 1.9% and 1.5%, respectively. Sperm Motility and, to a lesser extent, morphology showed improvement in Both groups. Evidence of infection, namely increased numbers of white Blood cells and positive sperm culture, disappeared in both the Doxycycline-treated and placebo group. It is concluded that features Of MAGI in semen may regress spontaneously and are not influenced by The doxycycline treatment. The concomitant improvement of sperm Motility and morphology still does not seem to enhance the Probability of conception.
SOURCE: Int J Androl 1986 Apr;9(2):91-8 81
(back to top) NLM CIT. ID: 86249889
Dynamics of spermatogenesis, hormonal and immune response of patients Suffering from chronic prostatitis and sterility under bitemporal Treatment with an ultra-high frequency electric field.
Bogolyubov VM; Karpukhin IV; Bobkova AS Razuvayev AV; Kozhinova EV
A new method of treatment of patients with chronic prostatitis and Sterility by means of ultra-high frequency (60 W) electric field Applied bitemporally has been proposed. During treatment 82% of the Patients showed an increase in the number of spermatozoa in 1 ml of Ejaculate; the percentage of movable and morphologically normal Spermatozoa has increased. Patients with chronic prostatitis and Sterility showed in the prostatic secrete before treatment a Predominance of B-lymphocytes over T-lymphocytes. After treatment the Number of T-lymphocytes in the prostatic secrete increased and the Content of B-lymphocytes decreased. In the subpopulation of T- Lymphocytes the content of T-suppressors increased, the content of T- Helpers and O-lymphocytes decreased. At the same time patients with Sterility showed an increase in blood testosterone level and an FSH Decrease. Out of 67 wives of the patients with sterility 50 reported Pregnancy within 6 months after beginning of the treatment.
SOURCE: Int Urol Nephrol 1986;18(1):89-97 83
(back to top) NLM CIT. ID: 86046437
Genital mycoplasma infections]
VERNACULAR TITLE: Genitale Mykoplasma-Infektionen.
Werni R; Mardh PA Ger
REGISTRY NUMBERS: 0 (Antibiotics)
Clinical and experimental investigations on the significance of Mycoplasma hominis and Ureaplasma urealyticum have revealed different And contradictory results. Both germs are frequently discovered in Young, sexually active persons. Ureaplasma urealyticum might be the Cause of some cases of non-gonococcal urethritis. M. Hominis seems to Be one causative agent of endometritis, salpingitis, parametritis and Septicaemia after birth; we do not know yet, however, how often this May be the case. M. Hominis may also infect the newborn, e.g., it may Cause meningitis and encephalitis. The diagnosis of an infection with Mycoplasmas is mainly based on the isolation of the organism, the Lack of other pathogens in the lesions, and the demonstration of a Significant change of titer of homologous antibodies. Tetracycline is The drug of choice; alternatives are clindamycin for M. Hominis and Erythromycin for U. Urealyticum.
SOURCE: Z Hautkr 1985 Sep 15;60(18):1486-505 84
(back to top) NLM CIT. ID: 85175756
The clinical presentation of Chlamydia trachomatis in a urological Practice.
Grant JB; Brooman PJ; Chowdhury SD; Sequeira P Blacklock NJ
Fifty-nine men with Chlamydia trachomatis (CT) infection have been Studied. Epididymitis was the most common presentation (26) compared With urethritis (8) and prostatitis (9). Only 13 patients gave a History of a urethral discharge. Fifteen of 21 female consorts Screened were CT positive and 13 of these were asymptomatic. This Demonstrates the major aetiological role of CT in lower genitourinary Infection and indicates the importance of screening and treating Consorts.
SOURCE: Br J Urol 1985 Apr;57(2):218-21 86
(back to top) NLM CIT. ID: 85264641
Diagnosis of genital Mycoplasma and Ureaplasma infections.
Friberg J
Genital Mycoplasma and Ureaplasma have been implicated in pelvic Inflammatory disease, puerperal infections, septic abortions, low Birth weight, nongonococcal urethritis and prostatitis as well as Spontaneous abortion and infertility. An unequivocal diagnosis of Infection with these organisms can be made only after properly Obtained specimens have been evaluated with the use of selective Cultures.
SOURCE: J Reprod Med 1985 Mar;30(3 Suppl):258-61 87
(back to top) NLM CIT. ID: 85143335
Inflammatory conditions and semen quality among subfertile Sudanese Males.
Omer EF
Fifty-nine subfertile males were investigated to assess seminal Quality, inflammatory conditions and spermatogenic picture in Relation to their subfertility. Defects in semen analysis were found Associated with an old gonococcal infection (42.4%), schistosomiasis (13.6%) and chronic prostatitis (5.1%). Varicocele was observed in a Few patients (3.4%). Azoospermia was found in 40.7%, of whom 33.3% Were found to suffer from spermatogenic arrest.
SOURCE: Trop Doct 1985 Jan;15(1):27-8 88
(back to top) NLM CIT. ID: 86024553
Value of intraprostatic injection of zinc and vitamin C and of Ultrasound application in infertile men with chronic prostatitis.
Fahim MS; Ibrahim HH; Girgis SM; Essa HA; Hanafi S
REGISTRY NUMBERS: 50-81-7 (Ascorbic Acid) 7440-66-6 (Zinc)
Seventy infertile men with chronic prostatitis were treated by Prostatic massage and wide-spectrum chemotherapy as basic treatment To which intraprostatic injection of zinc or vitamin C with or Without ultrasound application was added as a new line of treatment. Comparison showed no significant improvement of the additive Treatment over the conventional treatment used alone. Pus cells in The expressed prostatic smear diminished significantly after Treatment, which was associated with significant increase of Percentage of motile spermatozoa and significant decrease of abnormal Forms. Bacterial flora was studied in comparison with findings in 20 Cases of infertile males without prostatitis; staphylococci Predominated in both patient and control groups.
SOURCE: Arch Androl 1985;14(1):81-7 89
(back to top) NLM CIT. ID: 85143640
Ureaplasmal infections of the male urogenital tract, in particular Prostatitis, and semen quality.
Weidner W; Krause W; Schiefer HG; Brunner H Friedrich HJ
REGISTRY NUMBERS: 7440-66-6 (Zinc)
Ureaplasma urealyticum is considered an etiologic agent in urogenital Tract infections, especially prostatitis. Using the 'four-specimen Technique', diagnosis can be based upon significant numbers of these Microorganisms. In ejaculate, the critical number seems to be 10(3) Cfu/ml of semen to discriminate between real infection and Contamination during urethral passage. In our study, 46 of 412 Samples (11.2%) exceeded this critical number. Most but not all Patients suffering from ureaplasma-associated prostatitis established By the 'four-specimen technique' revealed significantly high Ejaculate numbers, whereas all samples from patients with Prostatodynia and healthy controls had lower numbers. In these cases, Numbers of round cells in semen, i.e. All leukocytes and spermatides, Were significantly increased as compared to prostatodynia. A Significantly negative correlation was detected between the numbers Of ureaplasmas and zinc concentration in semen, and an almost Identically negative correlation to the content of fructose, thus Indicating secretory dysfunction of the accessory glands in Ureaplasmal infections of the prostate.
SOURCE: Urol Int 1985;40(1):5-9 90
(back to top) NLM CIT. ID: 86185751
Seminal biochemistry and sperm characteristics in infertile men with Bacteria in ejaculate.
Grizard G; Janny L; Hermabessiere J; Sirot J Boucher D
REGISTRY NUMBERS: EC (Acid Phosphatase) 0 (Citrates) 30237-26-4 (Fructose) 77-92-9 (Citric Acid)
Sperm examination, quantitative sperm culture, citric acid, acid Phosphatase, and fructose were assayed in three groups of men: Fertile controls without significant bacteriospermia (group I), Infertile men with significant bacteriospermia; idiopathic infertile Men (group II), and infertile men with varicocele (group III). Level Of significance of bacteriospermia was greater than or equal to 10(4) Germs/ml of ejaculate. In group II, motility and typical morphology Percentages were lower, independently of the degree and the nature of Bacteriospermia. Incidence of pathogenic bacteria was higher than in Group III and linked to the degree of bacteriospermia. Fructose was Unaltered in the two groups of infected men. No modification of Prostatic markers was observed in any groups, except in group II, Where they decreased when bacteriospermia was lower than 10(5) Germs/ml and when biological pattern of semen evoked chronic Prostatitis. Thus, the presence of germs in ejaculate alters the Motility and the typical morphology percentages but does not result In any obvious modifications of biochemical markers of prostate and Seminal vesicles. For idiopathic infertile men, it is suggested that The quantitative criterion of pathogenic bacteriospermia is a germ Count greater than or equal to 10(5)/ml.
SOURCE: Arch Androl 1985;15(2-3):181-6 91
(back to top) NLM CIT. ID: 85044741
Infertility and chronic prostatitis.
Giamarellou H; Tympanidis K; Bitos NA; Leonidas E Daikos GK
REGISTRY NUMBERS: 0 (Antibiotics)
Long term treatment of chronic prostatitis with antimicrobials and Their influence on semen quality and infertility were studied in 30 Men with mean age of 36.7 +/- 6 years. The infection was symptomatic Only in 50% of the patients with abnormal prostatic physical findings In 66.7%. Cardinal findings in the spermatogram were leukocytosis in 100% and oligoasthenozoospermia in 66.5% of the patients. E. Coli and Staphylococci presented the most commonly isolated bacteria in Prostatic secretion cultures. Various treatment schedules, including Mostly co-trimoxazole, doxycycline and erythromycin, were given Alternatively for 6-8 months. Symptoms were cured or improved in 79.7%, with elimination or improvement of abnormal physical findings In 85%, while the isolated pathogens were eradicated in all. Spermatograms were normalized or improved in 70% of the patients, While among them 9 impregnated their wives and in 2 of them twice. It Is concluded that male infertility in the presence of semen Leukocytosis and oligoasthenozoospermia should be investigated for Underlying chronic prostatitis, while whenever proved, long term Treatment with the proper antimicrobials not only cures or improves Chronic prostatitis, but subsequently cures or improves male Infertility.
SOURCE: Andrologia 1984 Sep-Oct;16(5):417-22 93
(back to top) NLM CIT. ID: 85118046
Calcium, zinc, magnesium, concentration in seminal plasma of infertile Men with prostatitis.
Ponchietti R; Raugei A; Lanciotti E; Ademollo B Galvan P; Poggini G
REGISTRY NUMBERS: 7439-95-4 (Magnesium) 7440-66-6 (Zinc) 7440-70-2 (Calcium)
Seminal plasma, Zinc, Magnesium and Calcium concentrations were Evaluated in 15 infertile men with chronic prostatitis and in 10 Controls. Highly significant difference (p less than 0,01) was Observed in Calcium concentration only in the group of bacterial Prostatitis with respect to the controls. The possible significance Of these data is suggested.
SOURCE: Acta Eur Fertil 1984 Jul-Aug;15(4):283-5 94
(back to top) NLM CIT. ID: 85224512
Ureaplasma-infected human sperm in infertile men.
Grossgebauer K; Hennig A
REGISTRY NUMBERS: 60-54-8 (Tetracycline)
The case of an infertile man with oligospermia and symptoms of Urethritis-prostatitis, whose spouse had a vaginal discharge, is Reported. Microbiological analysis of appropriate specimens revealed A strain of tetracycline-resistant ureaplasma urealyticum in both Patients. Using the transmission electron microscope, it was possible To demonstrate spermatozoal heads "infected" with microorganisms Strongly resembling ureaplasma urealyticum.
SOURCE: Arch Androl 1984;12 Suppl:35-41 97
(back to top) NLM CIT. ID: 85028079
Multiplication of Brucella canis in male reproductive organs and Detection of autoantibody to spermatozoa in canine brucellosis.
Serikawa T; Takada H; Kondo Y; Muraguchi T; Yamada J
REGISTRY NUMBERS: 0 (Autoantibodies)
Orchitis, epididymitis and prostatitis have been reported in male dogs Infected with Brucella canis (B. Canis), but the pathogenesis of Infertility in male dogs has not been clarified yet. We examined Localization of B. Canis in the tissue of infected male reproductive Organs and production of autoantibody to spermatozoa in male dogs by Immunofluorescence and unlabeled antibody peroxidase-antiperoxidase (PAP) methods and electron microscopy. B. Canis were found in the Cytoplasm of macrophages and epithelial cells in testis, epididymis And prostate. Particularly in the prostate, B. Canis multiplied in The cytoplasm of epithelial cells and emerged in the glandular lumen With destroyed epithelial cells. Head-to-head agglutination of Spermatozoa was found in the semen, urine and epididymal duct with Varying degrees of intensity among the infected dogs. Appearance of The spermagglutination began following the detection of B. Canis in Urine and semen, suggesting invasion of the organisms in male Reproductive organs. In the sera from the dogs orally inoculated with B. Canis, (Ig M), Ig G and Ig A anti-spermantibodies were detected in Parallel with the appearance of the serum spermagglutinating Activity. The heads of agglutinated spermatozoa in the epididymal Duct and semen were coated with Ig A antibody, which is considered to Be anti-spermautoantibody locally produced. The target of these Circulating and local antibodies was acrosome of the dog spermatozoa And spermatids. It seems probable that multiplication of B. Canis in Epithelial cells is the direct cause of damage to the infected cells, And the damage acts as a trigger of the production of autoantibody to Spermatozoa.
SOURCE: Dev Biol Stand 1984;56:295-305 99
(back to top) NLM CIT. ID: 84085207
Relationship between genital tract infections, sperm antibodies in Seminal fluid, and infertility.
Witkin SS; Toth A
To explore possible relationships between genital tract infections, Sperm antibodies, and infertility, seminal fluid from 100 men was Analyzed. Sperm antibodies, measured by an enzyme-linked Immunosorbent assay, were detected in 14 of 29 men (48%) with Culture-positive asymptomatic infections, 8 of 17 men (47%) with a History of prostatitis or urethritis, 11 of 33 men (33%) with either A varicocele or an abnormal semen analysis, and only 1 of 21 men (5%) With no infection and a normal semen analysis. The incidence of sperm Antibodies in the men with infections or urethritis or prostatitis Was significantly higher than in the control subjects (P less than 0.005). The sperm antibody isotype in men with infections was mainly Iga, although igg or igm were also sometimes present. Of the men with Asymptomatic infections, urethritis or prostatitis, significantly (P Less than 0.025) more men without sperm antibodies (12 of 24, 50%) Were fertile than were those with sperm antibodies (3 of 22, 13%). Men with genital tract infections have a high incidence of Antibodies, reactive with spermatozoa, which is associated with Reduced fertility.
SOURCE: Fertil Steril 1983 Dec;40(6):805-8


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