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NLM CIT. ID:87193339
Zinc in human semen
Canale D; Bartelloni M; Negroni A; Meschini P
Izzo PL; Bianchi B; Menchini-Fabris GF
Seminal zinc was measured in normospermic and infertile patients by a
New colorimetric method. Analysis of semen from 5 patients with
Bilateral agenesis of the vas deferens showed high levels of zinc
(mean value 1411.2 micrograms/ml). Lower levels were found in 6
Patients with monolateral congenital or acquired obstruction (695.2
Micrograms/ml). The seminal zinc level in 6 patients who had had a
Vasectomy or who had an epididymal blockage (125.7 micrograms/ml) was
Approximately the same as in 41 controls (134.6 +/- 42 +/- SD). Zinc
Levels were reduced in hypogonadal patients. These data suggest that
Zinc is secreted mainly by the prostate, while vesicular, epididymal
And testicular secretions are devoid of zinc. Evaluation of this
Metal therefore permits the diagnosis of patency of the seminal
Pathways, but does not permit identification of prostatitis. No
Correlation was found between sperm count or motility and the seminal
Zinc level, nor between the latter and varicocele.
NLM PUBMED CIT. ID:
3570537
SOURCE: Int J Androl 1986 Dec;9(6):477-80
77
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NLM CIT. ID: 87112664
Immunosuppression and sperm antibody formation in men with
Prostatitis.
Witkin SS; Zelikovsky G
16 men with chronic prostatitis were evaluated immunologically in
Order to examine possible relationships between prostate infection,
Defective cellular immune responses and the occurrence of sperm
Antibodies. Peripheral blood mononuclear cells (PBMN) from 14 of 16
(88%) patients exhibited reduced or absent responses in vitro when
Incubated with an extract of Candida albicans. PBMN proliferation in
Response to the mitogen Concanavalin A (Con A) was reduced in 5 of 16
(31%) men. In addition, sera from 6 patients inhibited the
Candida-induced proliferative response of control PBMC; 2 of these
Sera also reduced the Con A-directed response. Sperm antibodies,
Evaluated by an enzyme- linked immunosorbent assay (ELISA) using
Fresh motile spermatozoa, were found in 9 of 16 (56%) patients. PBMC
Responses were reduced in all, and suppressive sera present in 5, of
The men with sperm antibodies. Igg antibodies predominated. 4 of the
Sera positive by ELISA also agglutinated spermatozoa. Levels of igg
Sperm antibodies were correlated with the degree of immunosuppression
By patient sera (p less than 0.02). These data suggest that decreased
Cellular immunity and enhanced humoral reactivity to sperm are common
In men with chronic prostatitis. Both may contribute to an increased
Rate of prostatic infection in these men.
NLM PUBMED CIT. ID:
3543373
SOURCE: J Clin Lab Immunol 1986 Sep;21(1):7-10
79
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NLM CIT. ID: 86290812
Significance and problems of Chlamydia detection in urologic
Patients]
VERNACULAR TITLE:
Bedeutung und Problematik des Chlamydiennachweises bei urologischen
Patienten.
Krech T; Gerhard-Fsadni D; Miller SM; Hofmann N
Chlamydiae represent the aetiological agent in non-gonococcal
Urethritis in about 50% of the cases, but it is also increasingly
Recognized that Chlamydia trachomatis can cause prostatitis or
Epididymitis. The introduction of methods for the direct detection of
Chlamydia in clinical materials allows early diagnosis and therefore
Effective antibiotic therapy. The new tests however give both false
Positive and false negative results.
NLM PUBMED CIT. ID:
3526694
SOURCE: Urologe [A] 1986 May;25(3):153-6
80
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NLM CIT. ID: 87082350
The effect of doxycycline in infertile couples with male accessory
Gland infection: a double blind prospective study.
Comhaire FH; Rowe PJ; Farley TM
Male accessory gland infection (MAGI, epididymo-prostato-vesiculitis)
With abnormal semen quality was rarely the only abnormality in
Infertile couples since it occurred in no more than 1.6% of 2871
Couples evaluated in 7 centres during a 3-year period. Both partners
Of 33 infertile couples with no other demonstrable abnormality than
Abnormal semen and MAGI consented to participate in a double blind
Trial and were treated with either doxycycline, 100 mg/day for 1
Month (20 couples) or placebo (13 couples). Follow-up during a total
Of 175 couple-months included semen analysis and the recording of
Pregnancy. Pregnancy occurred in 2 of the doxycycline-treated couples
(10%) and in 1 of the placebo treated couples (8%), corresponding
With conception rates per month of 1.9% and 1.5%, respectively. Sperm
Motility and, to a lesser extent, morphology showed improvement in
Both groups. Evidence of infection, namely increased numbers of white
Blood cells and positive sperm culture, disappeared in both the
Doxycycline-treated and placebo group. It is concluded that features
Of MAGI in semen may regress spontaneously and are not influenced by
The doxycycline treatment. The concomitant improvement of sperm
Motility and morphology still does not seem to enhance the
Probability of conception.
NLM PUBMED CIT. ID:
3539821
SOURCE: Int J Androl 1986 Apr;9(2):91-8
81
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NLM CIT. ID: 86249889
Dynamics of spermatogenesis, hormonal and immune response of patients
Suffering from chronic prostatitis and sterility under bitemporal
Treatment with an ultra-high frequency electric field.
Bogolyubov VM; Karpukhin IV; Bobkova AS
Razuvayev AV; Kozhinova EV
A new method of treatment of patients with chronic prostatitis and
Sterility by means of ultra-high frequency (60 W) electric field
Applied bitemporally has been proposed. During treatment 82% of the
Patients showed an increase in the number of spermatozoa in 1 ml of
Ejaculate; the percentage of movable and morphologically normal
Spermatozoa has increased. Patients with chronic prostatitis and
Sterility showed in the prostatic secrete before treatment a
Predominance of B-lymphocytes over T-lymphocytes. After treatment the
Number of T-lymphocytes in the prostatic secrete increased and the
Content of B-lymphocytes decreased. In the subpopulation of T-
Lymphocytes the content of T-suppressors increased, the content of T-
Helpers and O-lymphocytes decreased. At the same time patients with
Sterility showed an increase in blood testosterone level and an FSH
Decrease. Out of 67 wives of the patients with sterility 50 reported
Pregnancy within 6 months after beginning of the treatment.
NLM PUBMED CIT. ID:
3087902
SOURCE: Int Urol Nephrol 1986;18(1):89-97
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NLM CIT. ID: 86046437
Genital mycoplasma infections]
VERNACULAR TITLE:
Genitale Mykoplasma-Infektionen.
Werni R; Mardh PA
Ger
REGISTRY NUMBERS:
0 (Antibiotics)
Clinical and experimental investigations on the significance of
Mycoplasma hominis and Ureaplasma urealyticum have revealed different
And contradictory results. Both germs are frequently discovered in
Young, sexually active persons. Ureaplasma urealyticum might be the
Cause of some cases of non-gonococcal urethritis. M. Hominis seems to
Be one causative agent of endometritis, salpingitis, parametritis and
Septicaemia after birth; we do not know yet, however, how often this
May be the case. M. Hominis may also infect the newborn, e.g., it may
Cause meningitis and encephalitis. The diagnosis of an infection with
Mycoplasmas is mainly based on the isolation of the organism, the
Lack of other pathogens in the lesions, and the demonstration of a
Significant change of titer of homologous antibodies. Tetracycline is
The drug of choice; alternatives are clindamycin for M. Hominis and
Erythromycin for U. Urealyticum.
NLM PUBMED CIT. ID:
3904251
SOURCE: Z Hautkr 1985 Sep 15;60(18):1486-505
84
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NLM CIT. ID: 85175756
The clinical presentation of Chlamydia trachomatis in a urological
Practice.
Grant JB; Brooman PJ; Chowdhury SD; Sequeira P
Blacklock NJ
Fifty-nine men with Chlamydia trachomatis (CT) infection have been
Studied. Epididymitis was the most common presentation (26) compared
With urethritis (8) and prostatitis (9). Only 13 patients gave a
History of a urethral discharge. Fifteen of 21 female consorts
Screened were CT positive and 13 of these were asymptomatic. This
Demonstrates the major aetiological role of CT in lower genitourinary
Infection and indicates the importance of screening and treating
Consorts.
NLM PUBMED CIT. ID:
3986459
SOURCE: Br J Urol 1985 Apr;57(2):218-21
86
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NLM CIT. ID: 85264641
Diagnosis of genital Mycoplasma and Ureaplasma infections.
Friberg J
Genital Mycoplasma and Ureaplasma have been implicated in pelvic
Inflammatory disease, puerperal infections, septic abortions, low
Birth weight, nongonococcal urethritis and prostatitis as well as
Spontaneous abortion and infertility. An unequivocal diagnosis of
Infection with these organisms can be made only after properly
Obtained specimens have been evaluated with the use of selective
Cultures.
NLM PUBMED CIT. ID:
4020782
SOURCE: J Reprod Med 1985 Mar;30(3 Suppl):258-61
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NLM CIT. ID: 85143335
Inflammatory conditions and semen quality among subfertile Sudanese
Males.
Omer EF
Fifty-nine subfertile males were investigated to assess seminal
Quality, inflammatory conditions and spermatogenic picture in
Relation to their subfertility. Defects in semen analysis were found
Associated with an old gonococcal infection (42.4%), schistosomiasis
(13.6%) and chronic prostatitis (5.1%). Varicocele was observed in a
Few patients (3.4%). Azoospermia was found in 40.7%, of whom 33.3%
Were found to suffer from spermatogenic arrest.
NLM PUBMED CIT. ID:
3976003
SOURCE: Trop Doct 1985 Jan;15(1):27-8
88
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NLM CIT. ID: 86024553
Value of intraprostatic injection of zinc and vitamin C and of
Ultrasound application in infertile men with chronic prostatitis.
Fahim MS; Ibrahim HH; Girgis SM; Essa HA; Hanafi S
REGISTRY NUMBERS:
50-81-7 (Ascorbic Acid)
7440-66-6 (Zinc)
Seventy infertile men with chronic prostatitis were treated by
Prostatic massage and wide-spectrum chemotherapy as basic treatment
To which intraprostatic injection of zinc or vitamin C with or
Without ultrasound application was added as a new line of treatment.
Comparison showed no significant improvement of the additive
Treatment over the conventional treatment used alone. Pus cells in
The expressed prostatic smear diminished significantly after
Treatment, which was associated with significant increase of
Percentage of motile spermatozoa and significant decrease of abnormal
Forms. Bacterial flora was studied in comparison with findings in 20
Cases of infertile males without prostatitis; staphylococci
Predominated in both patient and control groups.
NLM PUBMED CIT. ID:
3901948
SOURCE: Arch Androl 1985;14(1):81-7
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NLM CIT. ID: 85143640
Ureaplasmal infections of the male urogenital tract, in particular
Prostatitis, and semen quality.
Weidner W; Krause W; Schiefer HG; Brunner H
Friedrich HJ
REGISTRY NUMBERS:
7440-66-6 (Zinc)
Ureaplasma urealyticum is considered an etiologic agent in urogenital
Tract infections, especially prostatitis. Using the 'four-specimen
Technique', diagnosis can be based upon significant numbers of these
Microorganisms. In ejaculate, the critical number seems to be 10(3)
Cfu/ml of semen to discriminate between real infection and
Contamination during urethral passage. In our study, 46 of 412
Samples (11.2%) exceeded this critical number. Most but not all
Patients suffering from ureaplasma-associated prostatitis established
By the 'four-specimen technique' revealed significantly high
Ejaculate numbers, whereas all samples from patients with
Prostatodynia and healthy controls had lower numbers. In these cases,
Numbers of round cells in semen, i.e. All leukocytes and spermatides,
Were significantly increased as compared to prostatodynia. A
Significantly negative correlation was detected between the numbers
Of ureaplasmas and zinc concentration in semen, and an almost
Identically negative correlation to the content of fructose, thus
Indicating secretory dysfunction of the accessory glands in
Ureaplasmal infections of the prostate.
NLM PUBMED CIT. ID:
3883615
SOURCE: Urol Int 1985;40(1):5-9
90
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NLM CIT. ID: 86185751
Seminal biochemistry and sperm characteristics in infertile men with
Bacteria in ejaculate.
Grizard G; Janny L; Hermabessiere J; Sirot J
Boucher D
REGISTRY NUMBERS:
EC 3.1.3.2 (Acid Phosphatase)
0 (Citrates)
30237-26-4 (Fructose)
77-92-9 (Citric Acid)
Sperm examination, quantitative sperm culture, citric acid, acid
Phosphatase, and fructose were assayed in three groups of men:
Fertile controls without significant bacteriospermia (group I),
Infertile men with significant bacteriospermia; idiopathic infertile
Men (group II), and infertile men with varicocele (group III). Level
Of significance of bacteriospermia was greater than or equal to 10(4)
Germs/ml of ejaculate. In group II, motility and typical morphology
Percentages were lower, independently of the degree and the nature of
Bacteriospermia. Incidence of pathogenic bacteria was higher than in
Group III and linked to the degree of bacteriospermia. Fructose was
Unaltered in the two groups of infected men. No modification of
Prostatic markers was observed in any groups, except in group II,
Where they decreased when bacteriospermia was lower than 10(5)
Germs/ml and when biological pattern of semen evoked chronic
Prostatitis. Thus, the presence of germs in ejaculate alters the
Motility and the typical morphology percentages but does not result
In any obvious modifications of biochemical markers of prostate and
Seminal vesicles. For idiopathic infertile men, it is suggested that
The quantitative criterion of pathogenic bacteriospermia is a germ
Count greater than or equal to 10(5)/ml.
NLM PUBMED CIT. ID:
3833075
SOURCE: Arch Androl 1985;15(2-3):181-6
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NLM CIT. ID: 85044741
Infertility and chronic prostatitis.
Giamarellou H; Tympanidis K; Bitos NA; Leonidas E
Daikos GK
REGISTRY NUMBERS:
0 (Antibiotics)
Long term treatment of chronic prostatitis with antimicrobials and
Their influence on semen quality and infertility were studied in 30
Men with mean age of 36.7 +/- 6 years. The infection was symptomatic
Only in 50% of the patients with abnormal prostatic physical findings
In 66.7%. Cardinal findings in the spermatogram were leukocytosis in
100% and oligoasthenozoospermia in 66.5% of the patients. E. Coli and
Staphylococci presented the most commonly isolated bacteria in
Prostatic secretion cultures. Various treatment schedules, including
Mostly co-trimoxazole, doxycycline and erythromycin, were given
Alternatively for 6-8 months. Symptoms were cured or improved in
79.7%, with elimination or improvement of abnormal physical findings
In 85%, while the isolated pathogens were eradicated in all.
Spermatograms were normalized or improved in 70% of the patients,
While among them 9 impregnated their wives and in 2 of them twice. It
Is concluded that male infertility in the presence of semen
Leukocytosis and oligoasthenozoospermia should be investigated for
Underlying chronic prostatitis, while whenever proved, long term
Treatment with the proper antimicrobials not only cures or improves
Chronic prostatitis, but subsequently cures or improves male
Infertility.
NLM PUBMED CIT. ID:
6496959
SOURCE: Andrologia 1984 Sep-Oct;16(5):417-22
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NLM CIT. ID: 85118046
Calcium, zinc, magnesium, concentration in seminal plasma of infertile
Men with prostatitis.
Ponchietti R; Raugei A; Lanciotti E; Ademollo B
Galvan P; Poggini G
REGISTRY NUMBERS:
7439-95-4 (Magnesium)
7440-66-6 (Zinc)
7440-70-2 (Calcium)
Seminal plasma, Zinc, Magnesium and Calcium concentrations were
Evaluated in 15 infertile men with chronic prostatitis and in 10
Controls. Highly significant difference (p less than 0,01) was
Observed in Calcium concentration only in the group of bacterial
Prostatitis with respect to the controls. The possible significance
Of these data is suggested.
NLM PUBMED CIT. ID:
6524259
SOURCE: Acta Eur Fertil 1984 Jul-Aug;15(4):283-5
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NLM CIT. ID: 85224512
Ureaplasma-infected human sperm in infertile men.
Grossgebauer K; Hennig A
REGISTRY NUMBERS:
60-54-8 (Tetracycline)
The case of an infertile man with oligospermia and symptoms of
Urethritis-prostatitis, whose spouse had a vaginal discharge, is
Reported. Microbiological analysis of appropriate specimens revealed
A strain of tetracycline-resistant ureaplasma urealyticum in both
Patients. Using the transmission electron microscope, it was possible
To demonstrate spermatozoal heads "infected" with microorganisms
Strongly resembling ureaplasma urealyticum.
NLM PUBMED CIT. ID:
6535453
SOURCE: Arch Androl 1984;12 Suppl:35-41
97
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NLM CIT. ID: 85028079
Multiplication of Brucella canis in male reproductive organs and
Detection of autoantibody to spermatozoa in canine brucellosis.
Serikawa T; Takada H; Kondo Y; Muraguchi T; Yamada J
REGISTRY NUMBERS:
0 (Autoantibodies)
Orchitis, epididymitis and prostatitis have been reported in male dogs
Infected with Brucella canis (B. Canis), but the pathogenesis of
Infertility in male dogs has not been clarified yet. We examined
Localization of B. Canis in the tissue of infected male reproductive
Organs and production of autoantibody to spermatozoa in male dogs by
Immunofluorescence and unlabeled antibody peroxidase-antiperoxidase
(PAP) methods and electron microscopy. B. Canis were found in the
Cytoplasm of macrophages and epithelial cells in testis, epididymis
And prostate. Particularly in the prostate, B. Canis multiplied in
The cytoplasm of epithelial cells and emerged in the glandular lumen
With destroyed epithelial cells. Head-to-head agglutination of
Spermatozoa was found in the semen, urine and epididymal duct with
Varying degrees of intensity among the infected dogs. Appearance of
The spermagglutination began following the detection of B. Canis in
Urine and semen, suggesting invasion of the organisms in male
Reproductive organs. In the sera from the dogs orally inoculated with
B. Canis, (Ig M), Ig G and Ig A anti-spermantibodies were detected in
Parallel with the appearance of the serum spermagglutinating
Activity. The heads of agglutinated spermatozoa in the epididymal
Duct and semen were coated with Ig A antibody, which is considered to
Be anti-spermautoantibody locally produced. The target of these
Circulating and local antibodies was acrosome of the dog spermatozoa
And spermatids. It seems probable that multiplication of B. Canis in
Epithelial cells is the direct cause of damage to the infected cells,
And the damage acts as a trigger of the production of autoantibody to
Spermatozoa.
NLM PUBMED CIT. ID:
6386574
SOURCE: Dev Biol Stand 1984;56:295-305
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NLM CIT. ID: 84085207
Relationship between genital tract infections, sperm antibodies in
Seminal fluid, and infertility.
Witkin SS; Toth A
To explore possible relationships between genital tract infections,
Sperm antibodies, and infertility, seminal fluid from 100 men was
Analyzed. Sperm antibodies, measured by an enzyme-linked
Immunosorbent assay, were detected in 14 of 29 men (48%) with
Culture-positive asymptomatic infections, 8 of 17 men (47%) with a
History of prostatitis or urethritis, 11 of 33 men (33%) with either
A varicocele or an abnormal semen analysis, and only 1 of 21 men (5%)
With no infection and a normal semen analysis. The incidence of sperm
Antibodies in the men with infections or urethritis or prostatitis
Was significantly higher than in the control subjects (P less than
0.005). The sperm antibody isotype in men with infections was mainly
Iga, although igg or igm were also sometimes present. Of the men with
Asymptomatic infections, urethritis or prostatitis, significantly (P
Less than 0.025) more men without sperm antibodies (12 of 24, 50%)
Were fertile than were those with sperm antibodies (3 of 22, 13%).
Men with genital tract infections have a high incidence of
Antibodies, reactive with spermatozoa, which is associated with
Reduced fertility.
NLM PUBMED CIT. ID:
6653800
SOURCE: Fertil Steril 1983 Dec;40(6):805-8
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