The Prostatitis Foundation

Prostatitis and infertility


(back to top) NLM CIT. ID: 84086910
Chronic prostatitis, chlamydia trachomatis and infertility.
Suominen J; Gronroos M; Terho P; Wichmann L
Seventy-one infertile men were studied for the presence of seminal Leucocytosis, and for the levels of acid phosphatase activity and Chlamydia trachomatis antibodies of iga class using a novel method of Solid-phase radioimmunoassay. The findings were compared with those Of 56 fertile men. Chlamydial iga antibodies were found in the semen Of 51.1% of infertile men with seminal leucocytosis and decreased Seminal acid phosphatase activity, i.e. Those defined as having Asymptomatic chronic prostatitis. This frequency was significantly Higher than among fertile men (23.2%, P less than 0.01) and those Infertile men who had no signs of chronic prostatitis (26.9%, P less Than 0.05). It is concluded that Chlamydia trachomatis seems to be a Common cause of prostatitis and may also interfere with fertility.
SOURCE: Int J Androl 1983 Oct;6(5):405-13 101
(back to top) NLM CIT. ID: 83241969
Bacterial infection and male infertility: absence of immunoglobulin A With specificity for common Escherichia coli 0-serotypes in seminal Fluid of infertile men.
Fowler JE Jr; Mariano M
REGISTRY NUMBERS: 0 (Antigens, Bacterial) 0 (Epitopes)
We used an indirect solid phase radioimmunoassay to detect and Quantitate immunoglobulin A (iga) in male genital secretions with Specificity for Escherichia coli (E. Coli) antigen. We assayed the Seminal fluid and expressed prostatic secretion (EPS) of a patient With chronic bacterial prostatitis (CBP) due to an 01 E. Coli, the Seminal fluid of 24 fertile men, and the seminal fluid of 62 men of Infertile marriages. Iga directed apparently against the 0-antigen of The infecting E. Coli was measurable in both the seminal fluid and EPS of the CBP patient. Iga in these specimens also bound to antigen In a mix of 8 common E. Coli 0-serotypes that included an 01 E. Coli. Iga with specificity for antigen in the mix of common E. Coli 0-serotypes could not be detected in the seminal fluid of the fertile Men or the men of infertile marriages. These data suggest that Subclinical E. Coli infections of the male reproductive tract are not Commonly associated with infertility.
SOURCE: J Urol 1983 Jul;130(1):171-4 102
(back to top) NLM CIT. ID: 83251342
Microbiological analysis of the ejaculate in andrology]
VERNACULAR TITLE: Mikrobiologische Ejakulatanalyse in der Andrologie.
Grossgebauer K Ger
Microbiological analysis of semen in andrology is mainly performed in Cases of infertility and artificial insemination. In order to Localize the suggested infection and to detect urethral (asymptomatic) colonization, we recommend to analyse additional Specimens of the patient, i.e. Urethral swabs and first portion of Urine. As a rule, quantitative microbiological analysis is necessary In cases of bacteria belonging to the group of potentially pathogenic Flora. In isolating pathogenic ("specific") bacteria, the detection Of a few microorganisms indicates an infectious process. We recommend The careful microscopical examination of the ejaculate to detect Phagocytes, abnormal spermatozoa, trichomonads, yeasts and other Cells. As a rapid microscopical examination we employ the DAPI-fluorochrome-technique. Microbiological cultures should take Into consideration the isolation and identification of ureaplasmas And chlamydia trachomatis. In order to achieve a comparison of Microbiological results with those of other laboratories, it is Essential to define the terms "significant bacteriospermia" and "significant leukocytospermia". In other words, it is necessary to Introduce a borderline between contamination and infection concerning The "nonspecific" potentially pathogenic flora.
SOURCE: Z Hautkr 1983 Apr 1;58(7):498-508 104
(back to top) NLM CIT. ID: 83229010
C-reactive protein in semen and serum of men with chronic prostatitis.
Girgis SM; Ekladios E; Iskandar RM; El-Haggar S Moemen N; El-Kassem SM
REGISTRY NUMBERS: 9007-41-4 (C-Reactive Protein)
Qualitative determination of C-RP in semen and serum of men with and Without prostatitis showed that, the protein is present mostly in Semen only in cases with prostatitis and with a significantly higher Percentage incidence in the infertile than the fertile.
SOURCE: Andrologia 1983 Mar-Apr;15(2):151-4 105
(back to top) NLM CIT. ID: 83073665
Anaerobic and aerobic bacteria in secretions of prostate and seminal Vesicles of infertile men.
Colpi GM; Zanollo A; Roveda ML; Tommasini-Degna A Beretta G
A cytological and bacteriological study was made of prostatic (EPS) And vesicular (EVS) secretions from 123 infertile men who were Suspected of having chronic genital tract inflammation and from 31 Men with premature ejaculation (1,12,16). In the microbiological Investigations samples were inoculated within 10 min on various Culture media and incubated under both aerobic and anaerobic Conditions. Bacterial loads of more than 10,000 colony-forming units Of a single species or genus per milliliter of EPS or EVS were Considered to be pathological. In the infertile subjects with proven Inflammation of the seminal accessory glands, the EPS and the EVS That gave positive cultures and had bacterial loads defined as Pathological contained large numbers of anaerobic or microaerophilic Organisms (EPS: 51 of the 63 bacterial strains found, congruent to 81%; EVS: 19 of the 20 bacterial strains found, congruent to 95%).
SOURCE: Arch Androl 1982 Sep;9(2):175-81 108
(back to top) NLM CIT. ID: 83020526
Male infertility: etiologic factors in 385 consecutive cases.
El-Bayoumi MA; Hamada TA; El-Mokaddem HH
During a three years period, evaluation of etiologic factors in 385 Consecutive infertile men revealed chronic prostato-vesiculitis as The commonest cause (25.7%) followed by varicocele (21.8%). In 77% of The patients with chronic prostatitis the authors found a decreased Spermatozoa motility rate. AN obstruction of the sperm duct was found In 7,8%, autoagglutination in 5.7%. Idiopathic infertility was Diagnosed in 10.9% of the patients. The significance of these Findings and the contributions of other causes in this series are Discussed.
SOURCE: Andrologia 1982 Jul-Aug;14(4):333-9 110
(back to top) NLM CIT. ID: 82249890
Study of the spermatic bacterial flora in infertile males (author's Transl)]
VERNACULAR TITLE: Etude de la flore microbienne spermatique chez des patients consultant Pour sterilite.
Granouillet R; Gaudin OG; Laurent JC; Rousset H Moulin A Fre
Two groups of infertile males (65 and 132 patients) have been Investigated in two different laboratories, with two different Methods to obtain semen. The bacteriological results are quite Similar in the two groups. The microorganisms which have been Isolated are : beta- hemolytic Streptococcus, Proteus, Epidermidis Staphylococcus, Micrococcus, Corynebacter, Viridans streptococcus, Klebsiella, Pseudomonas, Enterobacter, Bacillus, Neisseria, Escherichia coli, anaerobic Staphylococcus, anaerobic Streptococcus, Anaerobic Corynebacter type IV. Fungus, Achromobacter, 20 p. Cent of The patients are chronically infected without any clinical signs. This infection is probably of prostatic origin with an important Number of bacteria in the semen (more than 3 000/ml). No relation has Been shown between the bacteriological data and the physical and Cytological characteristics of the sperm, except the ph : semens with A low ph are generally azoospermic and highly contaminated.
SOURCE: Sem Hop 1982 May 6;58(18):1129-33 111
(back to top) NLM CIT. ID: 82145683
Transabdominal sonography of seminal vesicles.
Jimenez-Cruz JF; Mayayo T; Lovaco F; Garcia J Navio S; Romero-Aguirre C
We evaluated 119 male patients for infertility and/or prostatitis. Transabdominal sonography of the seminal vesicles was performed and Transverse sections were used to measure the height and breadth. A Correlation was established with the characteristics of the semen, The volume of semen being related directly to the size of the Vesicles. Male patients with semen abnormalities had seminal vesicles Of greater diameters than those with normal semen. When patients with Prostatitis are eliminated from this group the difference is Insignificant.
SOURCE: J Urol 1982 Feb;127(2):260-2 112
(back to top) NLM CIT. ID: 82027880
Clinical significance of sperm antibodies in infertility.
Mathur S; Baker ER; Williamson HO; Derrick FC Teague KJ; Fudenberg HH
REGISTRY NUMBERS: 0 (Antibodies) 0 (Autoantibodies) 53-03-2 (Prednisone)
Sperm antibody (AB) titers, determined by passive hemagglutination and Cytotoxicity assays, were found to be elevated in 62 males and 46 Females of 103 couples with primary infertility; 15 males and 12 Females of 25 couples with secondary infertility; 10 males and 8 Females of 18 couples with histories of repeated abortion; 21 males And 17 females of 25 couples in which the husband had a history of Prostatitis; and 29 males and 17 females of 38 couples in which the Husband had oligospermia. Of the couples in which one or both Partners had elevated sperm AB titers, only 4 achieved pregnancy: 3 From the group with secondary infertility, all of which ended in Spontaneous abortions, and 1 in which the husband was oligospermic. This suggests an etiologic role of sperm immunity in infertility. Immunosuppressive treatment of autoimmune males with prednisone (15 Mg/day for 3 weeks to 6 months) resulted in significant decreases in AB titers. Pregnancies were achieved by 9 of 25 couples after Treatment (36%). The observed increase in pregnancy rate in the Prednisone-treated versus untreated groups of couples with elevated Sperm AB titers was significant (P less than 0.02).
SOURCE: Fertil Steril 1981 Oct;36(4):486-95 113
(back to top) NLM CIT. ID: 82021944
Diagnostic value of determination of acid and alkaline phosphatase Levels in the seminal plasma of infertile males.
Girgis SM; Deinasury MK; El-Kodary M; Metawy B Moussa MM; Momen N; Saleh SM
REGISTRY NUMBERS: EC (Alkaline Phosphatase) EC (Acid Phosphatase)
To investigate the diagnostic value of phosphatases in seminal plasma, The levels of acid phosphatase and alkaline phosphatase were Determined in 15 fertile subjects as well as in 26 cases of Oligoasthenozoospermia. Statistical analysis of obtained data showed That acid phosphatase is a reliable parameter of prostatic function In cases of infection, while alkaline phosphatase may prove to be a Non- specific parameter of subfertile semen. Alkaline phosphatase was Significantly diminished in both oligozoospermia and azoospermia with And without infection or varicocele.
SOURCE: Andrologia 1981 Jul-Aug;13(4):330-4 114
(back to top) NLM CIT. ID: 81006005
Diagnosis of accessory gland infection and its possible role in male Infertility.
Comhaire F; Verschraegen G; Vermeulen L
REGISTRY NUMBERS: EC (Acid Phosphatase) 30237-26-4 (Fructose)
The diagnosis of male adnexitis is difficult and the influence of this Condition on fertility is still a matter of debate. With the Intention to define diagnostic criteria a comprehensive study of Biochemical and morphological features of semen, plus culture for Microorganisms, was performed in patients who were assessed for Infertility during a four year period. The following parameters were Considered of diagnostic value: a) history of urogenital infection And/or abnormal rectal palpation. B) significant alterations in the Expressed prostatic fluid and/or urinary sediment after prostatic Massage. C) 1. Uniform growth of more than 10(3) pathogenic bacteria, Or more than 10(4) non- pathogenic bacteria per ml, in culture of Diluted seminal plasma. C) 2. Presence of more than 10(6) (peroxidase Positive) leucocytes per ml of ejaculate. C) 3. Signs of disturbed Secretory function of the prostate or seminal vesicles. The diagnosis Of infection is accepted if either of the following combinations if Found: a + b, a + c (1 or 2 or 3), b + c (1 or 2 or 3), c1 + c2, c1 + C3, c2 + c3.
SOURCE: Int J Androl 1980 Feb;3(1):32-45 120
(back to top) NLM CIT. ID: 80196376
The effect of massage treatment of prostatic congestion on the Prostatic size and secretion of citric acid.
Paz GF; Fainman N; Homonnai ZT; Kraicer PF
In this study, 25 men, referred to our clinic for diagnosis and Therapy of infertility were included. All had enlarged prostates. They were given 10 sessions of prostatic massage during 3--4 weeks And the fluid expressed was analysed for citric acid. The hypertrophy Was seen to recede in almost all cases. Citric acid concentrations Fell in only 6/25 cases analysed. In all the others, values did not Fall and remained relatively stable. There was no apparent Relationship between reduction of prostatic volume and the pattern of Citric acid secretion.
SOURCE: Andrologia 1980 Jan-Feb;12(1):30-3 122
(back to top) NLM CIT. ID: 80001004
Male infertility.
Hendry WF
The modern management of male subfertility is based on recognition and Correction of the underlying defect. Treatment starts nonspecifically With improvement in the general environment of spermatogenesis and Any surgical abnormalities are dealt with. If supplementary endocrine Treatment is necessary it is given rationally after estimation of Pituitary and testicular hormone levels. The presence or absence of Antisperm antibodies is established and their effect on sperm Behaviour is observed before and during treatment. Progress in Understanding the complex processes involved in human reproduction Requires careful observation of accurately defined facts. Much Research remains to be done.
SOURCE: Br J Hosp Med 1979 Jul;22(1):47-60 124
(back to top) NLM CIT. ID: 80029907
Prostatitis due to the circular form of trichomonas (author's Transl)]
VERNACULAR TITLE: Les prostatites a trichomonas formes rondes (T.F.R.).
Verges J Fre
The authors underline the frequency with which trichomoniasis is Located in the prostate. In these cases the parasite is rarely in its Trophozoite form but has a circular shape which resembles the Resistant pseudocystic type. They are found by phase contrast Microscopy after staining with 1% cresyl blue which makes the Difference with white blood cells. Out of a total of 178 men Presenting with urethroprostatic signs (urethral discharge and Burning), sterility with oligospermia, or a history of dyspareunia, The circular type of trichomoniasis was found in 40 (22%) of the Cases, with urethritis in 26 cases, and prostatitis in the other 14 Patients. Two courses of treatment, at one month's interval, with Tinidazole (2 tablets daily for 6 days) or Nimorazole (2 tablets Daily for 8 days) produced healing in 4 cases with urethroprostatic Effections, disappearance of dyspareunia in 2 out of the 3 cases Treated, and return of fertility in 3 out of 7 patients. An Up-to-date list of references is given.
SOURCE: J Urol Nephrol (Paris) 1979 Jun;85(6):357-61 125


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