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| Antimicrobial Agents and Chemotherapy, February 2000, p. 261-266, Vol.
44, No. 2
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Mehdi Shakibaei,
1Kerstin Pfister,
2
Rudolf Schwabe,
2
JÝrgen Vormann,3
and Ralf Stahlmann
2
,*
Institute of Anatomy, 1Institute of Clinical Pharmacology and Toxicology, 2and Institute of Molecular Biology and Biochemistry, 3Benjamin Franklin Medical Center, Freie Universität
Berlin, 14195 Berlin, Germany
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| ABSTRACT
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| Fluoroquinolones can cause tendinitis and tendon rupture. However,
toxicological as well as clinical information on quinolone-induced
tendopathy is scarce. We performed extensive electron microscopic
studies with Achilles tendon specimens from ofloxacin-treated rats. The
drug was given at a dose of 1,200 mg/kg (body weight) orally. Juvenile
Wistar rats received one or three oral doses each of 1,200 mg of
ofloxacin/kg (body weight)/day. |
| Three days after treatment, the
tenocytes of their Achilles tendons showed degenerative alterations,
such as multiple vacuoles and vesicles in the cytoplasm that had
developed due to swellings and dilatations of cell organelles. Other
indications of cell degradation were the occurrence of cell debris and
cell detachment from the extracellular matrix accompanied by a loss of
cell-matrix interaction. |
| The tenocytes of juvenile Wistar rats that had
been treated at day 36 with a single oral dose of 1,200 mg of
ofloxacin/kg (body weight) and sacrificed either 3 or 6 months later
exhibited similar degenerative alterations. The number of degenerative
alterations of tenocytes after ofloxacin treatment was considerably
higher in rats that had received a magnesium-deficient diet than in rats
with normal magnesium status. Of the adult rats that had been treated
once, 5 times, and 10 times with ofloxacin and killed 1 day later, only
those with the 10-times treatment showed a significantly increased
number of degeneratively altered tenocytes. In summary, effects observed
in tendons show similar pathological features as described earlier in
cartilage, indicating that quinolone-induced arthropathy and
quinolone-induced tendopathy probably are different clinical
manifestations of the same toxic effect on cellular components of
connective tissue structures. |
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