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The Effect Of Isolated Soy Protein On Plasma Biomarkers In Elderly Men With Elevated Serum Prostate Specific Antigen
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D. Urban; W. Irwin; M. Kirk; M. A. Markiewicz; R. Myers; M. Smith; H.
Weiss; W. E. Grizzle; S. Barnes
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From the Division of Urology, Departments of Surgery, Pathology and
Pharmacology and Toxicology, and Biostatistics Unit and Mass
Spectrometry Shared Facility, Comprehensive Cancer Center, University of
Alabama at Birmingham and Pharmacy Department, University of Alabama
Hospital, Birmingham, Alabama |
THE JOURNAL OF UROLOGY 2001;165:294-300 |
ABSTRACT |
Purpose: We performed a randomized double-blind crossover pilot study in
elderly men with elevated prostate specific antigen (PSA) on the effects
of the daily consumption of 2 soy beverages, each containing 20 gm. of
isolated soy protein, on the isoflavone concentration in blood and
urine, and on the 3 serum biomarkers cholesterol, PSA and the soluble
p105 component of the p185erbB-2 proto-oncogene. |
Materials and Methods: A total of 34 men supplemented their diet by
consuming 1 of 2 soy protein beverages assigned randomly twice daily for
a 6-week period. In a second 6-week period they consumed the other soy
protein beverage. The beverage ISP+ provided 42 mg. of genistein and 27
mg. of daidzein daily, whereas the other beverage, ISP-, provided only
2.1 and 1.3 mg. of these isoflavones daily, respectively. Blood and
24-hour urine samples were obtained before the study, at 2-week
intervals during the study and 2 weeks after study completion. |
Results: ISP+ and to a lesser extent ISP- substantially increased the
serum concentration and urinary output of the isoflavones and their
metabolites. Serum cholesterol was significantly decreased by ISP+
irrespective of the order in which the 2 soy beverages were administered
and in apparent correlation with the total isoflavone concentration.
There was no significant effect of the soy beverages on serum PSA and
p105erbB-2 values. |
Conclusions: This study reveals that short-term exposure of elderly men
with elevated serum PSA values to soy protein containing isoflavones
decreases serum cholesterol but not the serum biomarkers PSA and
p105erbB-2.
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This information is forwarded to you by the Prostatitis Foundation. We do not provide medical advice. We distribute literature and information relevant to prostatitis. While we encourage all research we do not endorse any doctor, medicine or treatment protocol. Consult with your own physician. |
© 2002 The Prostatitis Foundation |
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