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The Effect Of Isolated Soy Protein On Plasma Biomarkers In Elderly Men With Elevated Serum Prostate Specific Antigen

D. Urban; W. Irwin; M. Kirk; M. A. Markiewicz; R. Myers; M. Smith; H. Weiss; W. E. Grizzle; S. Barnes
From the Division of Urology, Departments of Surgery, Pathology and Pharmacology and Toxicology, and Biostatistics Unit and Mass Spectrometry Shared Facility, Comprehensive Cancer Center, University of Alabama at Birmingham and Pharmacy Department, University of Alabama Hospital, Birmingham, Alabama
THE JOURNAL OF UROLOGY 2001;165:294-300
Purpose: We performed a randomized double-blind crossover pilot study in elderly men with elevated prostate specific antigen (PSA) on the effects of the daily consumption of 2 soy beverages, each containing 20 gm. of isolated soy protein, on the isoflavone concentration in blood and urine, and on the 3 serum biomarkers cholesterol, PSA and the soluble p105 component of the p185erbB-2 proto-oncogene.
Materials and Methods: A total of 34 men supplemented their diet by consuming 1 of 2 soy protein beverages assigned randomly twice daily for a 6-week period. In a second 6-week period they consumed the other soy protein beverage. The beverage ISP+ provided 42 mg. of genistein and 27 mg. of daidzein daily, whereas the other beverage, ISP-, provided only 2.1 and 1.3 mg. of these isoflavones daily, respectively. Blood and 24-hour urine samples were obtained before the study, at 2-week intervals during the study and 2 weeks after study completion.
Results: ISP+ and to a lesser extent ISP- substantially increased the serum concentration and urinary output of the isoflavones and their metabolites. Serum cholesterol was significantly decreased by ISP+ irrespective of the order in which the 2 soy beverages were administered and in apparent correlation with the total isoflavone concentration. There was no significant effect of the soy beverages on serum PSA and p105erbB-2 values.
Conclusions: This study reveals that short-term exposure of elderly men with elevated serum PSA values to soy protein containing isoflavones decreases serum cholesterol but not the serum biomarkers PSA and p105erbB-2.

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